Endocrine Abstracts

Introduction: Primary hyperaldosteronism is a known cause of arterial hypertension, classically with hypokalaemia. About 30–40% of the cases are caused by unilateral aldosterone-producing adenoma, and the recommended treatment is adrenalectomy. Hypoaldestoronism is an uncommon complication of unilateral adrenalectomy, but it can be life-threatening. We present a case of severe hypoaldosteronism after unilateral adrenalectomy for the treatment of primary aldosteronism....

Introduction: Diamond-Blackfan anemia (DBA) is a severe congenital erythroid aplastic anemia with autosomal dominant inheritance. It is a rare disease (incidence 1/150000) and usually is discovered during the 2 first years after birth. Treatment includes steroids, blood transfusions and bone-marrow transplantation.Case report: A 31 year-old woman with DBA had received multiple treatments including transfusion support since birth. Consequently, she had de...

Introduction: Subclinical Cushing’s syndrome (SCS) is the most frequent endocrine dysfunction found in adrenal incidentalomas. Although adrenalectomy constitutes a therapeutic option for selected cases, the presence of bilateral tumours can difficult the surgical decision.Objective: Evaluate the utility of 131I-6β-iodomethyl-19-norcholesterol scintigraphy in SCS with bilateral adrenal tumours.Methods: Retrospec...

Thyroid cancer therapy is based on surgery followed by radioiodine treatment of tumor remnants and metastases. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS), normally present in thyroid follicular cells’ membrane. We studied the expression of NIS in a series of 229 thyroid primary tumors using real time PCR and immunohistochemistry, and searched for possible associations between NIS expression and clinicopathological feature...